ERBB2 and cancer: On the other hand, we found a significant association of elevated SQLE levels with high-grade tumors (Δ log2 expression = 0.51, 95% CI = 0.43–0.58, P < 2 × 10−16), node positive cancers (Δ log2 expression for NPLN greater or equal 4 vs. 0 = 0.17, 95% CI = 0.04–0.31, P = 0.0086 and NPLN 1–3 vs. 0 = 0.14, 95% CI = 0.03–0.24, P = 0.0072, overall P = 0.0011), and Her2 + neoplastic malignancies (Δ log2 expression = 0.41, 95% CI = 0.30–0.54, P = 1.7 × 10−11).