To explore the associations of SQLE expression with classical clinical and pathological variables in breast cancer, i.e. age, tumor size, number of positive lymph nodes (NPLN), histological grade, ER and Her2 status, we took advantage of the data generated by METABRIC, currently the single largest clinically annotated CN and GE breast cancer dataset publicly available31. This evidence concerns the gene ESR1 and breast carcinoma.