Of even greater relevance, in a Cox proportional hazards regression model starting from all the classical clinical and pathological parameters (i.e., age, tumor size, NPLN, histological grade, ER, and Her2 status), as well as both MYC and SQLE GE values, only SQLE was retained, together with clinico-pathological parameters, as an independently significant variable for survival prediction in the final model (adjusted HR for the SQLE high vs. low expression strata = 1.32, 95% CI = 1.03–1.68, P = 0.0267; overall P of the final model = 0, see Table 3 and Fig. 3D). Here, ESR1 is linked to neoplasm.