Other researchers observed SQLE overexpression in an adverse prognosis group of ER + , stage I/II breast cancer cases33, described aberrant methylation patterns in the 8q12.1-q24.22 genomic region chromosomal region35, or reported that SQLE amplification and increased transcription was enriched (together with other genes) in a distinctive cluster of triple negative breast tumors or in specific ethnic populations25, 34. The gene discussed is ESR1; the disease is breast cancer.