The degree of IGF-1 deficiency in these children is usually less marked than that in severe GH deficiency or in classical severe primary IGF-1 deficiency (Laron syndrome) patients (6) These non-GH-deficient (non-GHD) short stature children with low IGF-1 also cannot attain a normal adult height (3). This evidence concerns the gene GH1 and hyperinsulinemic hypoglycemia, familial, 4.