In ONX 0914 treated mice we found elevated serum levels of creatinine and urea on day 7 (Fig. 7A) and of TNF-α and IL-6 on day 3 and day 7 (Fig. 7B; data not shown) indicating that renal failure and sepsis might occur faster upon LMP7 inhibition. The gene discussed is PSMB8; the disease is acute kidney injury.