Different familiar forms of neurodegenerative diseases have been associated with mutations that enhance the pro-aggregating properties of specific proteins, such as α-synuclein in Parkinson’s disease13, 20, 21, tau or beta amyloid in Alzheimer’s22, 23 and huntingtin in Huntington’s disease24, 25, 26. The gene discussed is HTT; the disease is neurodegenerative disease.