SNP rs7070180 mapping to an intron of the GFRA1 gene, was associated with anti-TNF response in a cohort of 566 Caucasian RA patients in the UK (p = 2.24×10−4) and in a meta-analysis including a cohort of 379 additional patients (p = 6.42×10−5). Here, GFRA1 is linked to rheumatoid arthritis.