LRRC19 and colitis: Notably, in Lrrc19 KO mice that received WT bone marrow, the incidence and severity of colitis were significantly lower than those of WT mice transplanted with Lrrc19 KO BM (Figures S1D–S1F), suggesting that epithelial but not hematopoietic expression of LRCC19 is necessary for the proinflammatory role of LRRC19 in DSS colitis.