Interaction of CK1α and CARMA1 has already been shown to contribute to NF-κB activation in T cells and ABC DLBCL.21 Our results demonstrate that the function of CARMA1-CK1α binding is not mono-directional and only feeding into the NF-κB pathway, but also recruits and controls β-catenin in cells carrying oncogenic CARMA1 mutations. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.