In fact, CK1α binding and β-catenin stabilization was also detected for CARMA1 WT after P/I stimulation, which is consistent with previous reports showing β-catenin stabilization upon T-cell receptor and BCR engagement in a PKCθ- and PKCβ-dependent manner, respectively.35, 36 In line with BCR-dependent β-catenin stabilization, we found recruitment of the β-catenin destruction complex and elevated β-catenin expression in ABC DLBCL cell lines that display chronic BCR signaling as a result of upstream mutations, for example, in CD79B. Here, CARD11 is linked to diffuse large B-cell lymphoma.