WNT3A and neoplasm: Indeed, WNT3a secretion by a subpopulation of cells in a DLBCL population was shown to be able to induce WNT signaling, indicating that especially in primary samples the tumor microenvironment may contribute to increasing β-catenin amounts.40 Thus, the increased β-catenin levels could be at least partially a result of autocrine or paracrine WNT signals within the tumor microenvironment.