NFKB1 and breast cancer: An NF-κB—β-catenin cross-talk that modulates gene expression through physical interaction has already been observed in colon and breast cancer cells.33 Binding of β-catenin and p65 were shown to enhance tumorigenesis also in intestinal epithelial cells.34 Co-regulation of target genes may either rely on the direct binding of β-catenin and p65, but it can also function more indirectly at the level of transcriptional activation.