CARD11 and cancer: Previous studies have shown a physical interaction between β-catenin and NF-κB p65 in cancer cells.33, 34 We therefore tested if β-catenin and p65 associated in BJAB cells expressing oncogenic CARMA1 upon co-IP and found an interaction in the CARMA1 mutants F123I/K208M and L225LI-expressing BJAB cells that showed strongest β-catenin accumulation (Figure 7a).