The involvement of lysosomes in endometriosis has yet to be investigated in detail; to our knowledge, only one study describes changes in numbers of lysosomes in the endometrium of women with endometriosis.35 We also successfully knocked down ATG7 (in addition to other autophagic mediators) in T-HESC; we noted a marked increase in p21 protein expression, which was associated with attenuated cell viability with ATG7 siRNA (Supplementary Figure 1e); changes were observed with LC3B siRNA but only a subtle effect was noted with beclin-1 siRNA. The gene discussed is MAP1LC3B; the disease is endometriosis.