IAPs have been highly exploited to be targeted in anticancer therapeutics and have been proved to be a good addition to the list of apoptosis-inducing strategies.116 Small-molecule inhibitors act either by targeting IAPs by mimicking SMAC (inhibitor of IAPs) or by antisense-mediated interference of XIAP mRNA and protein expression.105 Refer to Table 5 for the list of IAPs in clinical settings against cancer. Here, XIAP is linked to cancer.