More importantly, Bodipy+ LDs colocalizated with fewer and larger lysosomes, a morphological feature for lysosomal storage disorders,34, 35 in WT macrophages but do with more and smaller lysosomes, a feature of new reformed functional lysosome,36 in Pdcd4 knockout mice (Figure 2c), suggesting that Pdcd4 deficiency promotes lipid breakdown in LD via elevating autophagy and improving lysosome function. Here, PDCD4 is linked to lysosomal storage disease.