SMAD4 and cancer: Among these genes, CDKN1B can be both tumor suppressor and oncogene according to TSGene (tumor suppressor gene) database.14 The BLC2 and BRAF are oncogenes whereas SMAD4 and NFKB1 are tumor suppressors.14 This analysis may provide an overview for cell senescence-related genes in different cancer stages with different senescent features.