We found 56 genes in the CSGene database associated with numerous chromatin regulatory processes in HIV infection (Supplementary Table S4), including ‘Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter', ‘Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter', ‘Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA', and ‘Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones' (Table 2). Here, EP300 is linked to HIV infectious disease.