GLI1 and neoplasm: Some inhibitors of HH/GLI have contributed to the downregulation of the pathway targets in the stromal microenvironment, suggesting that the effect on HH/GLI signaling is dependent on the stroma and a paracrine signaling mechanism.44 Owing to the critical role of this signaling pathway in general tumor maintenance, intensive clinical studies utilizing several HH/GLI inhibitors have been performed.39, 45