The Hedgehog pathway is important for multiple tumor types, although this signaling pathway was initially suggested as necessary for only basal cell carcinoma and medulloblastoma.37 Additionally, aberrant HH/GLI signaling plays a critical role in commonly occurring tumors, such as non-small-cell lung cancers38 and many others.39 However, the common mechanism for the maintenance of the high survivin levels in tumors remained obscure. This evidence concerns the gene BIRC5 and basal cell carcinoma.