The Hedgehog pathway is important for multiple tumor types, although this signaling pathway was initially suggested as necessary for only basal cell carcinoma and medulloblastoma.37 Additionally, aberrant HH/GLI signaling plays a critical role in commonly occurring tumors, such as non-small-cell lung cancers38 and many others.39 However, the common mechanism for the maintenance of the high survivin levels in tumors remained obscure. The gene discussed is GLI1; the disease is medulloblastoma.