The mTOR plays a central role in the regulation of cell proliferation, growth, differentiation and survival.24 Dysregulation of this pathway is closely associated with a wide variety of cancers, including malignant GBMs.25, 26, 27 In addition, this pathway is also a canonical pathway that regulates autophagy in cells.28, 29 We determined whether autophagy impairment in GBM cells is a result of aberrant mTOR signaling. The gene discussed is MTOR; the disease is cancer.