We previously showed that EMC6 interacts with the Ras-related protein RAB5A and Beclin-1, and colocalizes with the omegasome marker Zinc finger FYVE domain-containing protein 1 (ZFYVE1) to regulate autophagosome formation in an osteosarcoma cell line.23 However, the precise mechanism through which EMC6 regulates the viability of tumor cells, especially GBM cells, remains largely unknown. Here, ZFYVE1 is linked to osteosarcoma.