EMC6 and Familial prostate cancer: For example, Burdelski et al.35 found that high levels of SQSTM1 were significantly linked to increased tumor cell proliferation in prostate cancers patients, indicating that impairment of autophagy is closely correlated with cancer cell proliferation.34 In this study, we found that EMC6 knockdown enhanced GBM cell proliferation, indicating that autophagy can negatively regulate GBM cancer cell proliferation.