EMC6 and rectal carcinoma: Homo sapiens and Mus musculus share 100% sequence homology for EMC6. 23 The EMC6 protein is located in the outer membrane of the endoplasmic reticulum (ER).23 Expression profile analysis indicated that EMC6 mRNA has been found in a variety of normal human tissues, including brain, pancreas, kidney, heart, liver, spleen, skeletal muscle and so on.23 Compared with these normal tissues, a lower level of EMC6 protein expression was found in a series of cancer tissues, including brain, esophageal and rectal carcinomas, among others (http://www.proteinatlas.org/ENSG00000127774-EMC6/tissue).