ZFYVE1 and glioblastoma: We previously showed that EMC6 interacts with the Ras-related protein RAB5A and Beclin-1, and colocalizes with the omegasome marker Zinc finger FYVE domain-containing protein 1 (ZFYVE1) to regulate autophagosome formation in an osteosarcoma cell line.23 However, the precise mechanism through which EMC6 regulates the viability of tumor cells, especially GBM cells, remains largely unknown.