According to these evidences, p53-null mice are considered as a model for increased bone remodeling and osteosclerosis.94 During MSC osteogenic differentiation, p53 can inhibit osteogenesis95, 96 along with the downregulating expression of critical osteogenic transcription factors including Osterix and Runx2.92 Higher bone density and formation rate have been reported in p53-deficient mice along with increased bone resorption, which is not directly regulated by p53.92 This evidence concerns the gene TP53 and osteosclerosis.