Interestingly, our previous work has proved that MSCs that lack p53 exhibit tumor-promoting characteristic through high secretion of nitric oxide (NO) and higher vigorous immunomodulation when compared with wild-type MSCs.128 We found that the higher secretion of NO from p53-deficient MSCs have an inhibitory effect on T cells, and promote tumor growth.128 Thus, loss of p53 function in MSCs can promote their transformation by regulating their immunoproperties, growth, and proliferation. This evidence concerns the gene TP53 and neoplasm.