The initiation of the tumor could, in part, be affected by a failure of MSCs in maintaining a balance with other differentiation gene programs, such as adipogenesis and chondrogenesis.78 Notably, p53−/−Rb−/− MSCs reflect the phenotype for the development of sarcoma.79 Interestingly, the feature of the osteoblast subtype of OS is tightly associated with the impaired activity of p53 in mouse MSCs and osteoblasts.85 The gene discussed is TP53; the disease is sarcoma.