Fructose-bisphosphate aldolase A, lamin-B2, 78 kDa glucose-regulated protein (GRP78), and isoform 2 of serine hydroxymethyltransferase were stained by five (38 %) of the 13 CC tested sera, whereas gluthathione S-transferase, retinal dehydrogenase and vimentin were only recognised by four (31 %) of the CC sera. This evidence concerns the gene ALDOA and cholangiocarcinoma.