ENO1 and cholangiocarcinoma: Hepatocytes are the principal site for carbohydrate metabolism, and three of the main targets we found (identified by at least 40 % of CC sera with the most appropriate antigenic extracts) were enzymes implicated more specifically in glycolysis and fructose-galactose metabolism: i.e., alpha-enolase, fructose biphosphate aldolase and glyceraldehyde3-phosphate dehydrogenase.