NOTCH4 and capillary hemangioma: Interestingly, some of these genes also play roles in cell signaling pathways that have been linked to the pathogenesis of infantile hemangioma [55]; namely, VEGFA in the VEGF/VEGFR pathway, ANGPT2 and ANGPTL1 in the Tie2/Angiopoietin signaling pathway and NOTCH3, NOTCH4 and JAG1 in the Notch pathway.