In the case of imatinib-resistant KIT-mutant GIST, these mutations cluster in the ATP-binding pocket (encoded by exons 13 and 14), and the activation loop (encoded by exons 17 and 18) of the kinase domain, and occur almost exclusively in the same gene and allele as the primary oncogenic driver mutation [10–13]. This evidence concerns the gene KIT and gastrointestinal stromal tumor.