Prele et al. demonstrated constitutively active STAT3 of lung fibroblasts isolated from patients with IPF resulted in reduced proliferative capacity, increased expression of anti-apoptotic gene Bcl-xL and Bcl-2, and reduced expression of Thy-1/CD90 and integrin avb3 [76, 77]. The gene discussed is THY1; the disease is idiopathic pulmonary fibrosis.