The United States (U.S.)Preventive Services Task Force [1], the American Cancer Society [2], the American College of Physicians [3], and the American Urological Association [4] recommend against the use of the prostate-specific antigen (PSA) test to detect prostate cancer in men aged 75 years and older or those with a life expectancy of less than 10 to 15 years, because the risk of harms outweighs potential benefits. The gene discussed is KLK3; the disease is cancer.