VEGFD and lymphangioleiomyomatosis: The diagnosis of LAM was established by histopathological examination (n = 81), by cytological examination of chylous fluid (n = 1), or by the combined findings of characteristic computed tomography (CT) and/or elevated serum VEGF-D (> 800 pg/mL) (n = 8) (see S1 Table for detailed clinical characteristics at the diagnosis of LAM).