We analyzed the mRNA levels of the YAP target genes CTGF and AREG. The results showed that these two genes were significantly upregulated in hypoxic HCC cells (Figure 3A), whereas the knockdown of YAP by siRNA (Figure 3A and 3B) attenuated the increase in the mRNA expression of CTGF and AREG (Figure 3A). Here, CCN2 is linked to hepatocellular carcinoma.