B7-H3 has emerged as a new potential target in TNBC and other cancer types, and its targeting by monoclonal and bispecific antibodies (MGA271; MacroGenics, MGD009; MacroGenics, H89; Memorial Sloan Kettering Cancer Center) are currently being studied in several phase I clinical trials in patients with B7-H3-positive cancers, including TNBC (ClinicalTrials.gov: NCT01391143, NCT0191893, NCT02 381314, NCT02475213, NCT01099644, NCT01502917, NCT00089245) [23, 24]. This evidence concerns the gene CD276 and cancer.