For example, Low serum IL-13 concentration was reported to be correlated with poor prognosis of colorectal cancer, [33] and IL-13 had been reported to can protect mice from papilloma formation during 9,10-dimethyl-1,2-benzanthracene/12-O-tetradecanoylphorbol-13-acetatetwo-step skin carcinogenesis via IL-4Rα induced signaling pathway. The gene discussed is IL4R; the disease is papilloma.