N-MYC has been found to upregulate P53 expression in neuroblastoma [62], but the protooncogene MDM2 which negatively regulates P53 is a direct transcriptional target of N-MYC, leading to increased MDM2 and subsequent decreased P53 function in MYCN-amplified neuroblastoma cells [63]. This evidence concerns the gene MDM2 and neuroblastoma.