By using adenoviral gene transduction of the carboxyl-terminal domain of FAK (AdFAK-CD), FAK phosphorylation was decreased [115] and AdFAK-CD decreased neuroblastoma cell proliferation, with a larger proportional decrease in proliferation of MYCN-amplified cells than MCYN non-amplified cells [116]. The gene discussed is PTK2; the disease is neuroblastoma.