CRP and cardiovascular disorder: Moreover, a diet high in wheat aleurone followed by 79 healthy subjects in a parallel, single-blinded intervention study induced a significantly increased plasma betaine after four weeks compared to the control group, being also effective in lowering plasma total homocysteine (tHcy) and LDL cholesterol [23], together with significantly lowering plasma levels of C-reactive protein, which is an independent risk factor for cardiovascular disease [24].