EGFR and breast cancer: There are also significant publications that support the role of EGFR transactivation in various diseases including lung cancer [46,49,62,63,64], breast cancer [51,65,66], oral cancer [67], gastrointestinal carcinoma [68,69], Osteoblasts [70], ovarian cancer [52,71,72], hepatocarcinoma [73], head and neck cancer [74], glioblastoma [75], heart disease [55,59], and renal fibrosis [76].