RPS6KB1 and cancer: As a serine/threonine protein kinase of the AGC kinase family, p70S6K is phosphorylated by different growth factors and insulin-like factors through the PI3K/mTOR pathway, and interacts with S6, eIF4B, eEF2K, PDCD4 and many other substrates; this is important for mitogen-induced cell proliferation, survival, motility and chemotherapy drug resistance in cancer cells [3].