RPS6KB1 and non-small cell lung carcinoma: To further understand the role of p70S6K inhibitors in non-small cell lung cancer, the present study assessed three NSCLC cell lines (A549, SK-MES-1, and NCI-H460) treated with PF-4708671, and evaluated the changes of malignant phenotypes such as proliferation, invasion and apoptosis evasion.