Acute myeloid leukemia (AML) with recurrent t(8;21)(q22;q22) [abbreviated as t(8;21)] and inv(16)(p13q22)/t(16;16)(p13;q22) [abbreviated as inv(16)] genetic abnormalities are termed as core-binding factor (CBF)-AML. The gene discussed is CEBPZ; the disease is acute myeloid leukemia.