Lrig1 KI/R26R-tdTomato/Ctnnb1lox(ex3)/+ mice had to be killed within 6 weeks of the start of the experiment, as they developed GI tumors, consistent with Lrig1 expression in the intestinal epithelium (Powell et al., 2012, Wong et al., 2012). This evidence concerns the gene LRIG1 and digestive system neoplasm.