Lgr5 KI/R26R-tdTomato/Ctnnb1lox(ex3)/+ mice entered anagen 2 weeks following 4-OHT application, and pilomatricomas, benign HF skin tumors (Chan et al., 1999, Lo Celso et al., 2004, Merrill et al., 2001), developed within 4 weeks (Figures 3A–3I). This evidence concerns the gene LGR5 and pilomatrixoma.