As the tumor lesions progressed in the back skin of 4-OHT-treated Lrig1 KI/R26R-tdTomato/Ctnnb1lox(ex3)/+ mice, collagen was comprehensively remodeled and the dermis was almost entirely filled with compact immature collagen characteristic of tumor stroma (Figure 6B). The gene discussed is LRIG1; the disease is neoplasm.