LGR6 and hydrops fetalis: The oncogenic effects of β-catenin activation in LGR6+ stem cell subpopulations not only caused different phenotypes depending on their location (IFE, dermatofibromas; HF junctional zone, infundibular cysts) but also took longer to develop in the IFE than the HF junctional zone, as recently reported for Hh-induced BCCs (Peterson et al., 2015).