PDIA3 and posterior cortical atrophy: This is supported by the following observations: 1) LEDGF/p75 overexpression leads to ERp57 transcript and protein upregulation in PCa cells, 2) LEDGF/p75 depletion leads to decreased ERp57 transcript expression in PCa cells, 3) LEDGF/p75 binds to and transactivates the ERp57 promoter region in PCa cells, and 4) LEDGF/p75 expression correlates with ERp57 expression in 65% of PCa tissues and 76% of control prostate tissues.