It is also plausible that basal expression levels of ERp57 in PCa cells are controlled by other transcription factors, and that the role of LEDGF/p75 is to enhance the transcription of this and other stress proteins (e.g. Hsp27, PRDX6) only when the cancer cells need to develop a stress survival response in the presence of a stressful or pro-inflammatory microenvironment characterized by unhealthy levels of oxidative stress. The gene discussed is PRDX6; the disease is cancer.