PSIP1 and cancer: This notion has been validated in numerous studies demonstrating a role for overexpressed LEDGF/p75 in promoting increased cell proliferation, clonogenicity, invasion, migration, angiogenesis, chemoresistance, and tumor volume in pre-clinical models of PCa and other cancers, whereas its depletion or inactivation causes decreased cell survival and tumor growth [12–14,16–22,30].