Also known as transcription co-activator p75, PC4 and SFRS1 interacting protein (PSIP1), and dense fine speckled autoantigen of 70 kD (DFS70), this multifunctional protein has gained relevance in the study of cancer, HIV-AIDS, autoimmunity, and eye disease (reviewed in refs. [9,10]). The gene discussed is PSIP1; the disease is cancer.