TGFB1 and Chagas disease: The intersections of multiple pathways and the shared genes/proteins within them provide a multi-dimensional systems view with a point of convergence, in particular with the AP1 transcription factor network being a central hub for cross-signaling events between the TGF-β signaling pathway, Cytokine-cytokine receptor interactions and Chagas disease pathways (Figs 6 and 7).