Recently, Kuwabara et al. showed that miR-451 exacerbates lipotoxicity in cardiac myocytes and cardiac hypertrophy in obese mice fed with high fat diet for 20 weeks (a physiological obese animal model for a prediabetic state of DMT2) through the direct interaction with Cab39, scaffold protein of liver kinase B1 (LKB1), which suppress the LKB1/AMPK pathway. Here, STK11 is linked to cardiac hypertrophy.