TNF and chronic kidney disease: TNF-α and INF-γ presented a significant negative correlation with ADAMTS13 activity/antigen ratio and a significant positive correlation with ADAMTS13 antigen, but not with ADAMTS13 activity, which is in agreement with the hypothesis that the inflammatory status induced by hyperglycemia may also result in reduced activity of ADAMTS13 and, consequently, in reduced proteolysis of VWF, leading to an imbalance between VWF and ADAMTS13 activity in DM1 patients with CKD.