As these cytokines can promote the release of procoagulant molecules, such as VWF [29], and possibly can reduce ADAMTS13 activity, promoting an imbalance between VWF and ADAMTS13 activity and, consequently, microthrombi formation, it is possible to suggest that the chronic low grade inflammation present in patients with CKD may be, at least partially, responsible for the link between diabetic nephropathy and high risk of cardiovascular outcomes. This evidence concerns the gene VWF and chronic kidney disease.