TNF and thrombophilia: In conclusion, increased plasma levels of proinflammatory cytokines INF-γ, TNF-α, and IL-6, anti-inflammatory cytokine IL-10, and haemostatic biomarkers VWF, ADAMTS13 antigen, ADAMTS13 activity, and D-Dimer are associated with CKD in DM1 patients, and the imbalance between VWF/ADAMTS13 activity and ADAMTS13 activity/antigen is correlated with inflammatory cytokines, suggesting that an interrelation between inflammation and hypercoagulability may contribute to the development and progression of renal disease in DM1.