In conclusion, increased plasma levels of proinflammatory cytokines INF-γ, TNF-α, and IL-6, anti-inflammatory cytokine IL-10, and haemostatic biomarkers VWF, ADAMTS13 antigen, ADAMTS13 activity, and D-Dimer are associated with CKD in DM1 patients, and the imbalance between VWF/ADAMTS13 activity and ADAMTS13 activity/antigen is correlated with inflammatory cytokines, suggesting that an interrelation between inflammation and hypercoagulability may contribute to the development and progression of renal disease in DM1. The gene discussed is TNF; the disease is kidney disorder.