EPCAM and non-small cell lung carcinoma: Other studies investigating EVs in relation to cancer showed that (I) vesicles from ascites of patients with colorectal cancer (CRC) may provide information on tumor development [48]; (II) claudin-containing exosomes in peripheral blood are associated with ovarian cancer [49]; (III) patients suffering from non-small cell lung cancer (NSCLC) can be distinguished from matched controls by a 30-marker model by phenotyping of EVs in plasma [50]; (IV) EpCAM-positive exosomes from NSCLC patients present increased levels of IGF-1R compared to healthy controls [51].