PRTN3 and granulomatosis with polyangiitis: She had received a diagnosis of GPA only a few days earlier, based on cutaneous vasculitis and neuropathy in the lower legs, sinusitis, pulmonary nodules, bilateral wrist arthritis, a markedly elevated PR3-ANCA level > 100 IU/mL (normal range 0–10 IU/mL), and histological findings from the nasal mucosa and lungs supportive of the disease.