MKI67 and neoplasm: In this study our objectives are (1) to evaluate the usefulness of Ki-67 index as well as traditional parameters such as mitoses and tumor size for predicting metastasis in LCTs and (2) to develop a systematic counting method for Ki-67 estimation in LCTs and compare the Manual Conventional Method (MCM) and the Computer Assisted Image Analysis Method (CIAM) for calculating Ki-67 index.