LGALS3 and obesity due to melanocortin 4 receptor deficiency: In the general population, levels of circulating galectin-3 have been shown to correlate positively with age, prevalence of obesity, diabetes, hypercholesterolemia, and hypertension, markers of inflammation, and target organ damage [33, 34], thus indicating a strict relationship of galectin-3 with metabolic disorders and associated risk factors and complications.