TP53 and cancer: While adducts, just as 8-OHdG, avoid DNA self-repair by 8-oxoguanine glycosylase (OGG1) and mutY DNA glycosylase (MUTYH), genetic mutations (point mutations mainly) could be caused, and cancer would initiate if the DNA mutations locate in cancer-related genes, such as Ras protooncogene and p53 cancer suppressor gene [25, 26, 151, 154].