The fully humanized antibody neutralizing IL-17A called AIN457 or Secukinumab (NCT01708603 Clinicaltrial.gov) is already approved for the first-line systemic treatment of moderate to severe plaque psoriasis [154, 155]; in MS patients, although it showed a reduction by 63% of new magnetic resonance imaging (MRI) lesions compared to placebo-treated patients, the reduction of annualized relapse rate (ARR) was not statistically significant [71]. The gene discussed is IL17A; the disease is myeloid sarcoma.