This was first suggested more than a decade ago, when several studies showed that tumor-derived VEGF-A, PlGF, TGF-β, and TNF-α contribute to recruitment of CD11b+ myeloid cells to the lungs in tumor-bearing mice before tumor dissemination and that this results in enhanced recruitment of metastatic cells to the lung [51–53]. The gene discussed is TGFB1; the disease is neoplasm.