As shown in Figure 3B, we observed that OR4F3 copy number variation could distinguish CHB from HBV-HCC with an area under curves (AUC) of 0.852 (95% confidence interval (CI), 0.829-0.895) as well as HBV-HCC from healthy controls (Con) with an AUC of 0.836 (95% CI, 0.824-0.872). Here, OR4F3 is linked to hepatocellular carcinoma.