HG-induced increase of DANGER mRNA and protein levels were verified in additional four NSCLC cell lines, NCI-H157, NCI-H23, NCI-H1299, and NCI-H358 (Supplementary Figure S1A, S1B) and we confirmed that elevated DANGER protein expression was sustained for at least 48 h after HG treatment (Supplementary Figure S1C). The gene discussed is ITPRIP; the disease is non-small cell lung carcinoma.