The hazard of death was increased 1) with every cm increase in tumor size (HR=1.05, p = 0.017); 2) with every unit increase in AFP levels (HR=1.0004, p = 0.041); and 3) in subjects with BCLC stage C compared to BCLC stage B (HR=3.23, p < 0.001). This evidence concerns the gene AFP and neoplasm.