The construction of LVs inserting effective human TIE2 and IFNα sequences into human Tie2 monocytes/macrophages (Escobar et al, 2014) and the notion that protocols of reduced‐intensity autologous stem cell transplantation already entered the clinical stage (Aiuti et al, 2013) represent relevant steps that should facilitate the access of our strategy in the clinic, thus providing a novel approach to treat hepatic CRC metastases in humans. This evidence concerns the gene IFNA1 and colorectal carcinoma.