Similar to the situation where all cells are responsive to IFNα, the comparison between Tie2‐GFP mice and Tie2‐IFNα mice bearing the IFNα/β receptor only on CRC cells and radio‐resistant cells (IFNα/βR−/− HSPCs into C57BL/6 mice) indicated a reduction in the overall volume of tumor lesions in the latter group (Fig 4A [bottom panels] and B, and Movie EV6). Here, IFNA1 is linked to neoplasm.