Consistent with the notion that small numbers of TEMs are detectable in the liver of HSPC‐transplanted mice independently of CRC cell injection (Fig 1B, D, and E, top panels), the hepatic content of Irf7 mRNA in Tie2‐GFP mice or Tie2‐IFNα mice that were injected with NaCl diverged, with the latter animals showing a larger than threefold increase over basal (Fig 3A). Here, IFNA1 is linked to colorectal carcinoma.