As expected, the comparison between Tie2‐GFP mice and Tie2‐IFNα mice in which all cells are responsive to IFNα (C57BL/6 HSPCs into C57BL/6 mice) showed a significant reduction in overall tumor volume in the latter group at both time points analyzed, confirming once more the anti‐tumor efficacy of our approach (Fig 4A [top panels] and B, and Movie EV4). Here, IFNA1 is linked to neoplasm.