A similar comparison between Tie2‐GFP mice and Tie2‐IFNα mice in which only CRC cells and cells of hematopoietic origin are responsive to IFNα (C57BL/6 HSPCs into IFNα/βR−/− mice) revealed tumor growth in both groups of animals (Fig 4A [middle panels] and B, and Movie EV5), indicating that IFNα/β receptor‐mediated signaling on radio‐resistant cells is necessary to confer anti‐tumor activity during the early phase of liver metastasis development. The gene discussed is TEK; the disease is colorectal carcinoma.