CD8A and colorectal carcinoma: To this end, the same Tie2‐IFNα mice above mentioned (described in Fig 2A–C) were infected systemically 84 days post‐CRC injection with a low dose (200 pfu/mouse) of lymphocytic choriomeningitis virus (LCMV), a non‐cytopathic mouse pathogen known to induce a transient IFN‐dependent BM aplasia followed by a robust CD8+ T‐cell response aimed at viral clearance (Binder et al, 1997; Iannacone et al, 2008).