The finding that the hepatic content of Irf7 mRNA in Tie2‐GFP animals slightly increased over time (from 5 min to day 7 after CT26‐RFP cell injection, Fig 3A) suggests that CRC cell expansion per se stimulates the release of low levels of endogenous IFNα; such levels of this cytokine, however, appear to be not sufficient to contain tumor growth. The gene discussed is IRF7; the disease is colorectal carcinoma.