Four days after transplantation—a time point in which Tie2‐GFP or Tie2‐IFNα cells are not yet emerged from the BM (Lechman et al, 2012; Zonari et al, 2013)—the animals were subjected to the first MRI analysis, which detected no significant differences in the number of lesions per liver of the two groups of mice (average metastasis number at day 4: Tie2‐GFP = 1.5 ± 0.4; Tie2‐IFNα = 2 ± 0.28) and in their total tumor volume (Fig 5B and C, and Movie EV8). This evidence concerns the gene TEK and neoplasm.