This concept is supported by the notion that IFNα‐responsive genes are induced—albeit to levels only slightly higher than controls—in the normal liver of mice carrying IFNα‐expressing TEMs and that patients with CRC suffering from chronic liver diseases associated with elevated levels of IFNα into the organ display reduced incidence of hepatic CRC metastases (Lieber, 1957; Iascone et al, 2005; Li Destri et al, 2013; Cai et al, 2014). The gene discussed is IFNA1; the disease is colorectal carcinoma.