IFNA1 and colorectal carcinoma: Nonetheless, our findings also illustrate that CRC metastatic growth is still impaired when TEMs themselves cannot respond to IFNα (when they lack the corresponding receptor), implicating that IFNα‐dependent signaling is not cell autonomous in these cells and that the anti‐tumor effect observed in this setting is independent of transgenic IFNα altering TEM differentiation or activation.