About 2 months after HSPC transplantation, Mock/Tie2‐GFP control mice and Tie2‐IFNα mice were injected intrasplenically with either the CRC cell line CT26 [H‐2d, BALB/c derived (Brattain et al, 1980)] or with the CRC cell line MC38 [H‐2b, C57BL/6 derived (Rosenberg et al, 1986)]. Here, IFNA1 is linked to colorectal carcinoma.