Lastly, to independently validate the anti‐metastatic effect of this strategy and to exclude the possibility that the observed phenotype was restricted to a specific tumor cell line, we intrasplenically injected a higher dose (5 × 104 cells/mouse) of MC38 cells into either Tie2‐GFP mice or Tie2‐IFNα mice transplanted as previously described. The gene discussed is TEK; the disease is neoplasm.