The strategy is based on the notion that a small subset of monocytes/macrophages expressing the angiopoietin receptor Tie2 (defined as Tie2+ monocytes/macrophages or TEMs) is recruited peritumorally in response also to hypoxic stimuli to support tumor vessel formation (De Palma et al, 2005; Mazzieri et al, 2011; Matsubara et al, 2013). Here, TEK is linked to neoplasm.