GRPR and Familial prostate cancer: In the current study, we used solid tumors from a patient-derived xenograft (PDX) of prostate cancer with high expression of GRPr as a model system that appears homogenous on histological H&E stains with high receptor density throughout the tumor as detected by in vitro autoradiography, which led us to expect a high and homogeneous in vivo uptake throughout the tumor.