Otherwise, Increased expression of CD68 (Fig. 4 a1, a2, a3) and CD163 (Fig. 4 b1, b2, b3) was also observed in tumor cells, whereas there was absence or reduced expression of E-cadherin (Fig. 4 c1, c2, c3), but strong cytoplasmic expression of vimentin (Fig. 4 d1, d2, d3) at the invasive front of the tumor. The gene discussed is VIM; the disease is neoplasm.