The incubation of TAMs CM resulted in a fibroblast-like appearance of cancer cells (HN4, HN6 and SCC9) together with the decreased/increased expression of E-cadherin/vimentin, which consistent with the findings suggest that TAMs are related with EMT transdifferentiation program in cancer cells by showing that downregulation of E-cadherin expression and acquisition of mesenchymal characteristics [31–33]. This evidence concerns the gene VIM and cancer.