The genotypic-phenotypic associations and effects on overall survival of cryptochrome genes reported in our CRC patients and the different CRY1 and CRY2 expression levels and time related profiles plus the different apoptotic, proliferative and cytotoxic responses observed in vitro in the studied colon cancer cell lines could be related to the dissimilarity of their chromosomal abnormalities and genetic background. The gene discussed is CRY1; the disease is malignant colon neoplasm.