NFKB1 and neoplasm: Essentially, cryptochrome gene mutation hampers tumorigenesis in p53-/- mice by means of: (i) stimulation of p53-independent apoptosis pathways, (ii) reduction of antiapoptotic action of NF-κB signaling upon inflammatory cytokine stimulation, (iii) purging of premalignant and malignant cells with hindrance of overt tumour formation [43].