CRY2 over-expression in human CRC samples may be caused by down-regulation of FBXW7, encoding F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase, which binds directly to phosphorylated Thr300 of CRY2 and tags this circadian protein for proteasomal degradation. The gene discussed is FBXW7; the disease is colorectal carcinoma.