CRY1 (median = 0.73, Q1-Q3 = 0.43-1.24, p < 0.01) and CRY2 (median = 0.50, Q1-Q3 = 0.25-0.77, p < 0.001) mRNA levels showed a statistically significant decrease in tumour tissues in comparison to matched non-tumorous tissues (Fig. 1a). This evidence concerns the gene CRY1 and neoplasm.