The aim of our study was to evaluate the expression patterns of CRY1 and CRY2 in neoplastic tissues of male and female CRC patients and in colon cancer cell lines in order to validate preliminary results previously obtained by our group [25] and explore the role of cryptochrome genes in colon cancer cell behaviour and response to chemotherapeutic agents. The gene discussed is CRY2; the disease is malignant colon neoplasm.