The protein encoded by FBXO32, also known as atrogin-1 and MAFbx, is an E3 ligase that is expressed selectively in skeletal muscles and cardiomyocytes and plays a critical role in muscle atrophy [8, 9], as well as in the development of cardiac hypertrophy and atrophy [10, 11]. This evidence concerns the gene FBXO32 and cardiac hypertrophy.