CD4 and sarcoidosis: As a prolonged state of macrophage activation and CD4+ T-lymphocyte accumulation in the presence of chronic antigenic stimulation is known to lead to inflammation in the early stage of sarcoidosis, “early sarcoid reaction” [36] and granuloma formation, an earlier study by Jazwa et al evaluated the expression of miR-15b and miR-16 as important regulators of CD4+ T cells [17].