Consistent with the data on mouse primary transformed cells, SD70 induced apoptosis (Figure 6I), differentiation (Figure S6B), and cell-cycle arrest (Figure S6C) accompanied with an increased level of H3K9me3 mark (Figure S6D) in MLL leukemia cell lines, suggesting a similar requirement of KDM4C activity in both human and mouse MLL leukemias. This evidence concerns the gene KMT2A and leukemia.