These results could also be faithfully reproduced using an independent KDM4C shRNA approach on the human MLL3 primary leukemia cells (Figure S6G), where the control cohort with scramble shRNA succumbed to leukemia with a short latency whereas the entire KDM4C knockdown group survived throughout the 90-day observation period (Figure S6G). This evidence concerns the gene KMT2C and leukemia.