We then tested whether Prmt1 swapping could also rescue leukemogenesis in vivo by transplanting primary HSPC immortalized with WT MOZ-TIF2 or MOZ-TIF2-Prmt1 (MT2ΔN79ΔAD2-Prmt1) into syngeneic mice for leukemia development. Here, NCOA2 is linked to leukemia.