Interestingly, there was a number of pathways commonly regulated by both Prmt1 and Kdm4c in these fusions: these include the Myc pathway and embryonic stem cell program (Figures 4E and 4F), which are important for MLL leukemia (Dawson et al., 2011, Somervaille et al., 2009) and other AML (Zuber et al., 2011). This evidence concerns the gene KMT2A and leukemia.