More than 35% (797 of 2,217, p = 3.28 × 10−57) of the genes and 60% (135 of 215) of the pathways significantly downregulated in MLL-AF9 transformed cells upon Kdm4c knockdown overlapped with those in MLL-GAS7, indicating a common requirement of Kdm4c in the maintenance of transcription programs in different MLL leukemias. This evidence concerns the gene KMT2A and leukemia.