Using primary c-kit+ HSPCs from this Prmt1flox/flox Cre-ER mouse for RTTA, we observed an even more prominent suppression of MLL-GAS7 transformed cells both in vitro (Figures S1I and S1J) and in vivo (Figure 1J) whereby none of the mice developed leukemia upon Prmt1 deletion. This evidence concerns the gene KMT2A and leukemia.