Interestingly, there was a number of pathways commonly regulated by both Prmt1 and Kdm4c in these fusions: these include the Myc pathway and embryonic stem cell program (Figures 4E and 4F), which are important for MLL leukemia (Dawson et al., 2011, Somervaille et al., 2009) and other AML (Zuber et al., 2011). The gene discussed is KMT2A; the disease is acute myeloid leukemia.