Surprisingly, only mice transplanted with WT MOZ-TIF2 induced leukemia in vivo with a median disease latency of 61 days, whereas no leukemia was found in the cohort injected with MOZ-TIF2-Prmt1 fusion immortalized cells (Figure 2L), suggesting that additional hitherto unidentified molecules may also be recruited by the N-terminal transformation domain and are required for leukemogenesis. This evidence concerns the gene PRMT1 and leukemia.